| http://purl.uniprot.org/citations/22871340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22871340 | http://www.w3.org/2000/01/rdf-schema#comment | "The antidiabetic intestinal L cell hormone glucagon-like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion and inhibits gastric emptying. GLP-1 secretion is stimulated by luminal oleic acid (OA), which crosses the cell membrane by an unknown mechanism. We hypothesized that L cell fatty acid transport proteins (FATPs) are essential for OA-induced GLP-1 release. Therefore, the murine GLUTag L cell model was used for immunoblotting, [(3)H]OA uptake assay, and GLP-1 secretion assay as determined by radioimmunoassay following treatment with OA ± phloretin, sulfo-N-succinimidyl oleate, or siRNA against FATP4. FATP4(-/-) and cluster-of-differentiation 36 (CD36)(-/-) mice received intraileal OA, and plasma GLP-1 was measured by sandwich immunoassay. GLUTag cells were found to express CD36, FATP1, FATP3, and FATP4. The cells demonstrated specific (3)H[OA] uptake that was dose-dependently inhibited by 500 and 1,000 μM unlabeled OA (P < 0.001). Cell viability was not altered by treatment with OA. Phloretin and sulfo-N-succinimidyl oleate, inhibitors of protein-mediated transport and CD36, respectively, also decreased [(3)H]OA uptake, as did knockdown of FATP4 by siRNA transfection (P < 0.05-0.001). OA dose-dependently increased GLP-1 secretion at 500 and 1,000 μM (P < 0.001), whereas phloretin, sulfo-N-succinimidyl oleate, and FATP4 knockdown decreased this response (P < 0.05-0.01). FATP4(-/-) mice displayed lower plasma GLP-1 at 60 min in response to intraileal OA (P < 0.05), whereas, unexpectedly, CD36(-/-) mice displayed higher basal GLP-1 levels (P < 0.01) but a normal response to intraileal OA. Together, these findings demonstrate a key role for FATP4 in OA-induced GLP-1 secretion from the murine L cell in vitro and in vivo, whereas the precise role of CD36 remains unclear."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.00116.2012"xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/author | "Miner J.H."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/author | "Stahl A."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/author | "Brubaker P.L."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/author | "Li S.K."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/author | "Dong C.X."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/author | "Poreba M.A."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/pages | "E899-907"xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/title | "Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells."xsd:string |
| http://purl.uniprot.org/citations/22871340 | http://purl.uniprot.org/core/volume | "303"xsd:string |
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