| http://purl.uniprot.org/citations/22872579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22872579 | http://www.w3.org/2000/01/rdf-schema#comment | "L-arginine (l-Arg) is an insulin secretagogue, but the molecular mechanism whereby it stimulates insulin secretion from β-cells is not known. The possibility that l-Arg regulates insulin secretion through a G protein-coupled receptor (GPCR)-mediated mechanism is suggested by the high expression of the nutrient receptor GPCR family C group 6 member A (GPRC6A) in the pancreas and TC-6 β-cells and the finding that Gprc6a(-/]minus]) mice have abnormalities in glucose homeostasis. To test the direct role of GPRC6A in regulating insulin secretion, we evaluated the response of pancreatic islets derived from Gprc6a(-/]minus]) mice to L-Arg. We found that the islet size and insulin content were decreased in pancreatic islets from Gprac6a(-/]minus]) mice. These alterations were selective for β-cells, because there were no abnormalities in serum glucagon levels or glucagon content of islets derived from Gprac6a(-/]minus]) mice. Significant reduction was observed in both the pancreatic ERK response to L-Arg administration to Gprc6a(-/]minus]) mice in vivo and L-Arg-induced insulin secretion and production ex vivo in islets isolated from Gprc6a(-/]minus]) mice. L-Arg stimulation of cAMP accumulation in isolated islets isolated from Gprc6a(-/]minus]) mice was also diminished. These findings suggest that l-Arg stimulation of insulin secretion in β-cells is mediated, at least in part, through GPRC6A activation of cAMP pathways."xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2012-1301"xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/author | "Pi M."xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/author | "Quarles L.D."xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/author | "Gerling I."xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/author | "Lenchik N.I."xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/pages | "4608-4615"xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/title | "GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets."xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/22872579 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22872579 |
| http://purl.uniprot.org/citations/22872579 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22872579 |
| http://purl.uniprot.org/uniprot/#_Q8K4Z6-mappedCitation-22872579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22872579 |
| http://purl.uniprot.org/uniprot/Q8K4Z6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22872579 |