| http://purl.uniprot.org/citations/22877752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22877752 | http://www.w3.org/2000/01/rdf-schema#comment | "HNF1α is a transcription factor that is expressed in pancreatic β-cells and mutations of the HNF1α gene cause a form of monogenic diabetes. To understand the role of HNF1α in pancreatic β-cells, we established the MIN6 β-cell line that stably expressed HNF1α-specific shRNA. Expression of the gene encoding hepatocyte growth factor (HGF) activator (Hgfac), a serine protease that efficiently activates HGF, was decreased in HNF1α KD-MIN6 cells. Down-regulation of Hgfac expression was also found in the islets of HNF1α (+/-) mice. Reporter gene analysis and the chromatin immunoprecipitation assay indicated that HNF1α directly regulates the expression of Hgfac in β-cells. It has been reported that HGF has an important influence on β-cell mass and β-cell function. Thus, HNF1α might regulate β-cell mass or function at least partly by modulating Hgfac expression."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.07.134"xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/author | "Yoshizawa T."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/author | "Yamagata K."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/author | "Ohki T."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/author | "Yamamura K."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/pages | "619-624"xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/title | "Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1alpha in mouse beta-cells."xsd:string |
| http://purl.uniprot.org/citations/22877752 | http://purl.uniprot.org/core/volume | "425"xsd:string |
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