| http://purl.uniprot.org/citations/22879925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22879925 | http://www.w3.org/2000/01/rdf-schema#comment | "The pleiotropic cytokine TGF-β has been implicated in the regulation of numerous aspects of the immune response, including naïve T cell homeostasis. Previous studies found that impairing TGF-β responsiveness (through expression of a dominant-negative TGF-β RII [DNRII] transgene) leads to accumulation of memory phenotype CD8 T cells, and it was proposed that this resulted from enhanced IL-15 sensitivity. Here we show naïve DNRII CD8 T cells exhibit enhanced lymphopenia-driven proliferation and generation of "homeostatic" memory cells. However, this enhanced response occurred in the absence of IL-15 and, unexpectedly, even in the combined absence of IL-7 and IL-15, which were thought essential for CD8 T cell homeostatic expansion. DNRII transgenic CD8 T cells still require access to self Class I MHC for homeostatic proliferation, arguing against generalized dysregulation of homeostatic cues. These findings suggest TGF-β responsiveness is critical for enforcing sensitivity to homeostatic cytokines that limit maintenance and composition of the CD8 T cell pool. (154 words)."xsd:string |
| http://purl.uniprot.org/citations/22879925 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0042268"xsd:string |
| http://purl.uniprot.org/citations/22879925 | http://purl.uniprot.org/core/author | "Johnson L.D."xsd:string |
| http://purl.uniprot.org/citations/22879925 | http://purl.uniprot.org/core/author | "Jameson S.C."xsd:string |
| http://purl.uniprot.org/citations/22879925 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22879925 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22879925 | http://purl.uniprot.org/core/pages | "e42268"xsd:string |
| http://purl.uniprot.org/citations/22879925 | http://purl.uniprot.org/core/title | "TGF-beta sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15."xsd:string |
| http://purl.uniprot.org/citations/22879925 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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