| http://purl.uniprot.org/citations/22884096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22884096 | http://www.w3.org/2000/01/rdf-schema#comment | "F-box proteins are components of the SCF (SkpA-Cullin 1-F-box) E3 ligase complexes, acting as the specificity-determinants in targeting substrate proteins for ubiquitination and degradation. In humans, at least 22 out of 75 F-box proteins have experimentally documented substrates, whereas in Drosophila 12 F-box proteins have been characterized with known substrates. To systematically investigate the genetic and molecular functions of F-box proteins in Drosophila, we performed a survey of the literature and databases. We identified 45 Drosophila genes that encode proteins containing at least one F-box domain. We collected publically available RNAi lines against these genes and used them in a tissue-specific RNAi-based phenotypic screen. Here, we present our systematic phenotypic dataset from the eye, the wing and the notum. This dataset is the first of its kind and represents a useful resource for future studies of the molecular and genetic functions of F-box genes in Drosophila. Our results show that, as expected, F-box genes in Drosophila have regulatory roles in a diverse array of processes including cell proliferation, cell growth, signal transduction, and cellular and animal survival."xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jgg.2012.05.009"xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/author | "Jiao R."xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/author | "Dui W."xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/name | "J Genet Genomics"xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/pages | "397-413"xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/title | "A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/22884096 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KHI0-mappedCitation-22884096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22884096 |
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| http://purl.uniprot.org/uniprot/#_A8DYA6-mappedCitation-22884096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22884096 |