| http://purl.uniprot.org/citations/22884633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22884633 | http://www.w3.org/2000/01/rdf-schema#comment | "The traffic of proteins to the outer segment of photoreceptors is a fundamentally important process, which when perturbed results in photoreceptor cell death. Recent reports have revealed a novel pathway for the traffic of lipid-modified proteins involving the small GTPase Arl3 and its effectors PDEδ and Unc119. The retinitis pigmentosa protein RP2 is a GTPase activating protein (GAP) for Arl3 and also appears to regulate the assembly and traffic of membrane associated protein complexes. We recently identified the Gβ subunit of transducin (Gβ1) as a novel RP2 interacting protein. Our data support a role for RP2 in facilitating membrane association and traffic of Gβ1, potentially prior to the formation of the obligate Gβ:Gγ heterodimer. Here, we review the recent evidence that suggests that RP2 co-operates with Arl3 and its effectors in protein complex assembly and membrane specification for lipid-modified proteins. This is exemplified by the co-ordination of cilia associated traffic for heterotrimeric G proteins and we propose a model for the role of Arl3 and RP2 in this process."xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.visres.2012.07.016"xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/author | "Cheetham M.E."xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/author | "Schwarz N."xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/author | "Hardcastle A.J."xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/name | "Vision Res"xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/pages | "2-4"xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/title | "Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins."xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/22884633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22884633 |
| http://purl.uniprot.org/citations/22884633 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22884633 |
| http://purl.uniprot.org/uniprot/#_A6NIH7-mappedCitation-22884633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/#_O75695-mappedCitation-22884633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/#_P36405-mappedCitation-22884633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/#_Q717R9-mappedCitation-22884633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/#_Q7Z494-mappedCitation-22884633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/Q7Z494 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/P36405 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/Q717R9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/O75695 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22884633 |
| http://purl.uniprot.org/uniprot/A6NIH7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22884633 |