| http://purl.uniprot.org/citations/22884897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22884897 | http://www.w3.org/2000/01/rdf-schema#comment | "Group III metabotropic glutamate receptors (mGluRs), which are generally located presynaptically, modulate synaptic transmission by regulating neurotransmitter release. Previously we showed enhanced amygdala-dependent cued fear conditioning in mGluR4(-/-) mice 24 h following training involving two tone-shock pairings. In this study, we assessed the effects of modulating mGluR4 signaling on acquisition and extinction of conditioned fear. mGluR4(-/-) and wild-type female and male mice received 10 tone-shock pairings during training. Compared to wild-type mice, mGluR4(-/-) mice showed enhanced acquisition and extinction of cued fear. Next, we assessed whether acute pharmacological stimulation of mGluR4 with the specific orthosteric mGluR4 agonist LSP1-2111 also affects acquisition and extinction of cued fear. Consistent with the enhanced acquisition of cued fear in mGluR4(-/-), LSP1-2111, at 2.5 and 5 mg/kg, inhibited acquisition of cued fear conditioning in wild-type male mice. The drug's effect on extinction was less clear and only a subtle effect was seen at 5 mg/kg. Finally, analysis of microarray data of amygdala tissues from mGluR4(-/-) versus wild-type and from wild-type mice treated with a mGluR4 agonist versus saline revealed a significant overlap in pattern of gene expression. Together, these data support a role for mGluR4 signaling in acquisition of fear learning and memory. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuropharm.2012.07.038"xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/author | "Davis M.J."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/author | "Raber J."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/author | "Duvoisin R.M."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/author | "Stewart B.M."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/author | "Acher F.C."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/author | "Eiwaz M.A."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/author | "Iancu O.D."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/name | "Neuropharmacology"xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/pages | "365-372"xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/title | "Role of mGluR4 in acquisition of fear learning and memory."xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/22884897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22884897 |
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