| http://purl.uniprot.org/citations/22886502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22886502 | http://www.w3.org/2000/01/rdf-schema#comment | "Myofibroblasts are implicated in pathological stromal responses associated with lung fibrosis. One prominent phenotypic marker of fully differentiated myofibroblasts is the polymerized, thick cytoplasmic filaments containing newly synthesized α-smooth muscle actin (α-SMA). These α-SMA-containing cytoplasmic filaments are important for myofibroblast contractility during tissue remodeling. However, the molecular mechanisms regulating the formation and maturation of α-SMA-containing filaments have not been defined. This study demonstrates a critical role for neuronal Wiskott-Aldrich syndrome protein (N-WASP) in regulating the formation of α-SMA-containing cytoplasmic filaments during myofibroblast differentiation and in myofibroblast contractility. Focal adhesion kinase (FAK) is activated by transforming growth factor-β1 (TGF-β1) and is required for phosphorylation of tyrosine residue 256 (Y256) of N-WASP. Phosphorylation of Y256 of N-WASP is essential for TGF-β1-induced formation of α-SMA-containing cytoplasmic filaments in primary human lung fibroblasts. In addition, we demonstrate that actin-related protein (Arp) 2/3 complex is downstream of N-WASP and mediates the maturation of α-SMA-containing cytoplasmic filaments. Together, this study supports a critical role of N-WASP in integrating FAK and Arp2/3 signaling to mediate formation of α-SMA-containing cytoplasmic filaments during myofibroblast differentiation and maturation."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00390.2011"xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Fang H."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Ding Q."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Zheng A."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Reichardt L.F."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Guan J.L."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Cai G.Q."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Chou C.F."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Thannickal V.J."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/author | "Luckhardt T.R."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/pages | "L692-702"xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/title | "Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of alpha-smooth muscle actin filaments during myofibroblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://purl.uniprot.org/core/volume | "303"xsd:string |
| http://purl.uniprot.org/citations/22886502 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22886502 |
| http://purl.uniprot.org/citations/22886502 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22886502 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPY3-mappedCitation-22886502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22886502 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPK4-mappedCitation-22886502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22886502 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQ85-mappedCitation-22886502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22886502 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BR46-mappedCitation-22886502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22886502 |