| http://purl.uniprot.org/citations/22890814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22890814 | http://www.w3.org/2000/01/rdf-schema#comment | "Animals lacking the inducible nitric oxide synthase gene (nos2(-/-)) are less susceptible to Mycobacterium avium strain 25291 and lack nitric oxide-mediated immunomodulation of CD4(+) T cells. Here we show that the absence of nos2 results in increased accumulation of neutrophils and both CD4(+) and CD8(+) T cells within the M. avium containing granuloma. Examination of the T-cell phenotype in M. avium infected mice demonstrated that CD4(+)CD44(hi) effector T cells expressing the Th1 transcriptional regulator T-bet (T-bet(+)) were specifically reduced by the presence of nitric oxide. Importantly, the T-bet(+) effector population could be separated into CD69(hi) and CD69(lo) populations, with the CD69(lo) population only able to accumulate during chronic infection within infected nos2(-/-) mice. Transcriptomic comparison between CD4(+)CD44(hi)CD69(hi) and CD4(+)CD44(hi)CD69(lo) populations revealed that CD4(+)CD44(hi)CD69(lo) cells had higher expression of the integrin itgb1/itga4 (VLA-4, CD49d/CD29). Inhibition of Nos2 activity allowed increased accumulation of the CD4(+) CD44(hi)T-bet(+)CD69(lo) population in WT mice as well as increased expression of VLA-4. These data support the hypothesis that effector T cells in mycobacterial granulomata are not a uniform effector population but exist in distinct subsets with differential susceptibility to the regulatory effects of nitric oxide."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201142158"xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Swain S."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Tighe M."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Cooper A.M."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Pearl J.E."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Torrado E."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Appelberg R."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Solache A."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Fountain J.J."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/author | "Strutt T."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/pages | "3267-3279"xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/title | "Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection."xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/22890814 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22890814 |
| http://purl.uniprot.org/citations/22890814 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22890814 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STZ4-mappedCitation-22890814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22890814 |
| http://purl.uniprot.org/uniprot/#_D3YC69-mappedCitation-22890814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22890814 |
| http://purl.uniprot.org/uniprot/#_P29477-mappedCitation-22890814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22890814 |
| http://purl.uniprot.org/uniprot/A0A1L1STZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22890814 |
| http://purl.uniprot.org/uniprot/P29477 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22890814 |
| http://purl.uniprot.org/uniprot/D3YC69 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22890814 |