| http://purl.uniprot.org/citations/22891283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22891283 | http://www.w3.org/2000/01/rdf-schema#comment | "Activated T cells secrete Fas ligand (FasL)-containing vesicles (secreted vesicles) that induce death of target cells. We provide evidence that secreted vesicles from culture supernatants (Csup) of various origins are able to generate both Fas-dependent apoptotic and Fas-independent, nonapoptotic cell death. In the absence of Fas, the nonapoptotic, Fas-independent pathway could still induce cell death. In contrast to RIP-independent classical Fas-induced cell death triggered by cross-linked or membrane-bound FasL, CSup-derived stimuli-induced apoptosis exhibited unique molecular and enzymatic characteristics. It could be partially inhibited by blocking cathepsin D enzyme activity and required the presence of RIP. Whereas stimulation with CSup, derived from both FasL-overexpressing Jurkat cells and PBMC, could induce cell death, the requirements for Fas-associated death domain protein and caspase-9 were different between the two systems. Our study highlights an important distinction between cell contact-mediated and secreted vesicle-generated activation-induced cell death and also demonstrates that the type of the secreted vesicles can also modify the cell death route. We propose that besides cell-to-cell interaction-mediated Fas triggering, stimuli induced by secreted vesicles can mediate important additional cell death signals regulating activation-induced cell death under physiological conditions."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1102827"xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/author | "Hueber A.O."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/author | "Chakrabandhu K."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/author | "Koncz G."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/author | "Rajnavolgyi E."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/author | "Gogolak P."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/author | "Kerekes K."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/author | "Hancz A."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/pages | "2815-2823"xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/title | "Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths."xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/22891283 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22891283 |
| http://purl.uniprot.org/citations/22891283 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22891283 |
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| http://purl.uniprot.org/uniprot/P25445#attribution-8CFAE0B795681BFE82BADD0DD63FA35B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22891283 |
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| http://purl.uniprot.org/uniprot/#_Q13546-mappedCitation-22891283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22891283 |