| http://purl.uniprot.org/citations/22892566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22892566 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism. We recently showed that presenilin-1 and -2, the catalytic components of γ-secretase, and γ-secretase activity itself, are highly enriched in a subcompartment of the endoplasmic reticulum (ER) that is physically and biochemically connected to mitochondria, called mitochondria-associated ER membranes (MAMs). We now show that MAM function and ER-mitochondrial communication-as measured by cholesteryl ester and phospholipid synthesis, respectively-are increased significantly in presenilin-mutant cells and in fibroblasts from patients with both the familial and sporadic forms of AD. We also show that MAM is an intracellular detergent-resistant lipid raft (LR)-like domain, consistent with the known presence of presenilins and γ-secretase activity in rafts. These findings may help explain not only the aberrant APP processing but also a number of other biochemical features of AD, including altered lipid metabolism and calcium homeostasis. We propose that upregulated MAM function at the ER-mitochondrial interface, and increased cross-talk between these two organelles, may play a hitherto unrecognized role in the pathogenesis of AD."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2012.202"xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Umeda M."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Bird T.D."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Schon E.A."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Sturley S.L."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Ikenouchi J."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Area-Gomez E."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Tambini M.D."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "de Groof A.J."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Guardia-Laguarta C."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Del Carmen Lara Castillo M."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/author | "Madra M."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/pages | "4106-4123"xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/title | "Upregulated function of mitochondria-associated ER membranes in Alzheimer disease."xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22892566 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22892566 |
| http://purl.uniprot.org/citations/22892566 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22892566 |
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| http://purl.uniprot.org/uniprot/#_Q60932-mappedCitation-22892566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22892566 |
| http://purl.uniprot.org/uniprot/#_Q61907-mappedCitation-22892566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22892566 |
| http://purl.uniprot.org/uniprot/#_Q9CY50-mappedCitation-22892566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22892566 |