| http://purl.uniprot.org/citations/22896810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22896810 | http://www.w3.org/2000/01/rdf-schema#comment | "Caffeine is a globally consumed psychostimulant but can be fatal to cells at overdose exposures. Although caspase-dependent apoptosis plays a role in caffeine-induced cell death, the responsible intracellular signalling cascade remains incompletely understood. The cellular slime mould, Dictyostelium discoideum, does not possess caspase-dependent apoptotic machinery. Here, we observed that ablation of D. discoideumplaA, which encodes a phospholipase A2 (PLA₂) homolog, leads to a decreased rate of cell death under high caffeine concentrations and to enhanced cell death with the addition of arachidonic acid. Moreover, the inhibition of PLA₂ activity lead to a recovery of the survival rate in caspase-inhibited Hela cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death is enhanced via PLA₂-dependent signalling. Our results indicate that arachidonic acid may be a general second messenger that negatively regulates caffeine tolerance via a caspase-independent cell death cascade, which leads to multiple effects in eukaryotic cells."xsd:string |
| http://purl.uniprot.org/citations/22896810 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep00577"xsd:string |
| http://purl.uniprot.org/citations/22896810 | http://purl.uniprot.org/core/author | "Kuwayama H."xsd:string |
| http://purl.uniprot.org/citations/22896810 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22896810 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/22896810 | http://purl.uniprot.org/core/pages | "577"xsd:string |
| http://purl.uniprot.org/citations/22896810 | http://purl.uniprot.org/core/title | "Arachidonic acid enhances caffeine-induced cell death via caspase-independent cell death."xsd:string |
| http://purl.uniprot.org/citations/22896810 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/22896810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22896810 |
| http://purl.uniprot.org/citations/22896810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22896810 |
| http://purl.uniprot.org/uniprot/Q54XY1#attribution-8D565B5F90A08AB3CF9574FD0E5CB404 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22896810 |
| http://purl.uniprot.org/uniprot/#_Q23917-mappedCitation-22896810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22896810 |
| http://purl.uniprot.org/uniprot/#_Q54XY1-mappedCitation-22896810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22896810 |
| http://purl.uniprot.org/uniprot/Q23917 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22896810 |
| http://purl.uniprot.org/uniprot/Q54XY1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22896810 |