| http://purl.uniprot.org/citations/22897851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22897851 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1. We show that TAL1 forms a positive interconnected autoregulatory loop with GATA3 and RUNX1 and that the TAL1 complex directly activates the MYB oncogene, forming a positive feed-forward regulatory loop that reinforces and stabilizes the TAL1-regulated oncogenic program. One of the critical downstream targets in this circuitry is the TRIB2 gene, which is oppositely regulated by TAL1 and E2A/HEB and is essential for the survival of T-ALL cells."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2012.06.007"xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Young R.A."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Gutierrez A."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Look A.T."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Barrasa M.I."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Ahn Y."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Sanda T."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Kelliher M.A."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Lawton L.N."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Kohlhammer H."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Fan Z.P."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Jamieson C.H."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/author | "Tatarek J."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/pages | "209-221"xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/title | "Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/22897851 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22897851 |
| http://purl.uniprot.org/citations/22897851 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22897851 |
| http://purl.uniprot.org/uniprot/#_P51946-mappedCitation-22897851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22897851 |