| http://purl.uniprot.org/citations/22898779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22898779 | http://www.w3.org/2000/01/rdf-schema#comment | "CKS proteins are evolutionarily conserved cyclin-dependent kinase (CDK) subunits whose functions are incompletely understood. Mammals have two CKS proteins. CKS1 acts as a cofactor to the ubiquitin ligase complex SCF(SKP2) to promote degradation of CDK inhibitors, such as p27. Little is known about the role of the closely related CKS2. Using a Cks2(-/-) knockout mouse model, we show that CKS2 counteracts CKS1 and stabilizes p27. Unopposed CKS1 activity in Cks2(-/-) cells leads to loss of p27. The resulting unrestricted cyclin A/CDK2 activity is accompanied by shortening of the cell cycle, increased replication fork velocity, and DNA damage. In vivo, Cks2(-/-) cortical progenitor cells are limited in their capacity to differentiate into mature neurons, a phenotype akin to animals lacking p27. We propose that the balance between CKS2 and CKS1 modulates p27 degradation, and with it cyclin A/CDK2 activity, to safeguard replicative fidelity and control neuronal differentiation."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2012.06.018"xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Tse E."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Dormann D."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Cervantes M."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Pommier Y."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Holic R."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Frontini M."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Cheng C.W."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Kukalev A."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Yu V."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Leo E."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/author | "Ng Y.M."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/pages | "356-370"xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/title | "The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment."xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22898779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22898779 |
| http://purl.uniprot.org/citations/22898779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22898779 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEY1-mappedCitation-22898779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22898779 |
| http://purl.uniprot.org/uniprot/#_D3YXP1-mappedCitation-22898779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22898779 |
| http://purl.uniprot.org/uniprot/#_D6RIK7-mappedCitation-22898779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22898779 |
| http://purl.uniprot.org/uniprot/#_P51943-mappedCitation-22898779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22898779 |