| http://purl.uniprot.org/citations/22899098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22899098 | http://www.w3.org/2000/01/rdf-schema#comment | "Lactation is an important event in all-mammalian species. To investigate the role of pregnancy-associated plasma protein (PAPP)-A in lactogenesis, we determined (i) PAPP-A expression in mouse mammary glands and (ii) the biological functions of PAPP-A in mammary epithelial cells. PAPP-A mRNA level was low during early mid pregnancy and increased during mid-late pregnancy, and then slightly decreased during lactation. Cell proliferation signals, but not differentiation, increased PAPP-A mRNA expression in HC11 mammary epithelial cells. Treatment of recombinant PAPP-A protein stimulated HC11 cell proliferation and suppressed the expression of β-casein mRNA, which is one of the milk proteins and cell differentiation marker. Surprisingly, in forcing expression experiment, PAPP-A increased β-casein mRNA expression. Our data suggest that PAPP-A has different roles on intracellular expressing and extracellular treatment to mammary epithelial cells. Taken together, in early pregnancy, circulating PAPP-A protein might be supplied from other organs and stimulates mammary gland growth. In contrast, during mid-late pregnancy, local PAPP-A expression begins and enhances cell differentiation within mammary epithelial cell."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12020-012-9766-0"xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/author | "Nagaoka K."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/author | "Taya K."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/author | "Watanabe G."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/author | "Mizutani T."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/author | "Kohsaka H."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/author | "Nakasato M."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/name | "Endocrine"xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/pages | "387-393"xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/title | "Pregnancy-associated plasma protein (PAPP)-A expressed in the mammary gland controls epithelial cell proliferation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/22899098 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22899098 |
| http://purl.uniprot.org/citations/22899098 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22899098 |
| http://purl.uniprot.org/uniprot/#_Q8R4K8-mappedCitation-22899098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22899098 |
| http://purl.uniprot.org/uniprot/Q8R4K8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22899098 |