| http://purl.uniprot.org/citations/22899650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22899650 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in PARK8, encoding leucine-rich repeat kinase 2 (LRRK2), are a frequent cause of Parkinson's disease (PD). Nonetheless, the physiological role of LRRK2 remains unclear. Here, we demonstrate that LRRK2 participates in canonical Wnt signaling as a scaffold. LRRK2 interacts with key Wnt signaling proteins of the β-catenin destruction complex and dishevelled proteins in vivo and is recruited to membranes following Wnt stimulation, where it binds to the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) in cellular models. LRRK2, therefore, bridges membrane and cytosolic components of Wnt signaling. Changes in LRRK2 expression affects pathway activity, while pathogenic LRRK2 mutants reduce both signal strength and the LRRK2-LRP6 interaction. Thus, decreased LRRK2-mediated Wnt signaling caused by reduced binding to LRP6 may underlie the neurodegeneration observed in PD. Finally, a newly developed LRRK2 kinase inhibitor disrupted Wnt signaling to a similar extent as pathogenic LRRK2 mutations. The use of LRRK2 kinase inhibition to treat PD may therefore need reconsideration."xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/dds342"xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://purl.uniprot.org/core/author | "Berwick D.C."xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://purl.uniprot.org/core/author | "Harvey K."xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22899650 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://purl.uniprot.org/core/pages | "4966-4979"xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://purl.uniprot.org/core/title | "LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6."xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/22899650 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22899650 |
| http://purl.uniprot.org/citations/22899650 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22899650 |
| http://purl.uniprot.org/uniprot/O35625#attribution-7D4286DD05DD02572638B96578AD4DC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/O35625#attribution-8E5F250C6934315FF6E1E2EFF81E38E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/Q02248#attribution-7D4286DD05DD02572638B96578AD4DC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/Q02248#attribution-8E5F250C6934315FF6E1E2EFF81E38E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/P51141#attribution-7D4286DD05DD02572638B96578AD4DC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/P51141#attribution-8E5F250C6934315FF6E1E2EFF81E38E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/Q61062#attribution-7D4286DD05DD02572638B96578AD4DC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/Q9WV60#attribution-7D4286DD05DD02572638B96578AD4DC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/Q9WV60#attribution-8E5F250C6934315FF6E1E2EFF81E38E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/O75581#attribution-7D4286DD05DD02572638B96578AD4DC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/O75581#attribution-8E5F250C6934315FF6E1E2EFF81E38E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/Q38SD2#attribution-5CFB17340D8E2F17D7C50F4CC4030507 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |
| http://purl.uniprot.org/uniprot/Q5S007#attribution-5CFB17340D8E2F17D7C50F4CC4030507 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22899650 |