| http://purl.uniprot.org/citations/22902232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22902232 | http://www.w3.org/2000/01/rdf-schema#comment | "γδ T cells respond rapidly to keratinocyte damage, providing essential contributions to the skin wound healing process. The molecular interactions regulating their response are unknown. Here, we identify a role for interaction of plexin B2 with the CD100 receptor in epithelial repair. In vitro blocking of plexin B2 or CD100 inhibited γδ T cell activation. Furthermore, CD100 deficiency in vivo resulted in delayed repair of cutaneous wounds due to a disrupted γδ T cell response to keratinocyte damage. Ligation of CD100 in γδ T cells induced cellular rounding via signals through ERK kinase and cofilin. Defects in this rounding process were evident in the absence of CD100-mediated signals, thereby providing a mechanistic explanation for the defective wound healing in CD100-deficient animals. The discovery of immune functions for plexin B2 and CD100 provides insight into the complex cell-cell interactions between epithelial resident γδ T cells and the neighboring cells they support."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.05.026"xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Fischer W.H."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Teyton L."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Verdino P."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Rieder S.E."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Kumanogoh A."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Cronin S.J."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Garijo O."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Havran W.L."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Witherden D.A."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Kikutani H."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/author | "Sarkisyan G."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/pages | "314-325"xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/title | "The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gammadelta T cell function."xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/22902232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22902232 |
| http://purl.uniprot.org/citations/22902232 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22902232 |
| http://purl.uniprot.org/uniprot/#_B2RXS4-mappedCitation-22902232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22902232 |
| http://purl.uniprot.org/uniprot/#_D3Z3P4-mappedCitation-22902232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22902232 |