| http://purl.uniprot.org/citations/22905719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22905719 | http://www.w3.org/2000/01/rdf-schema#comment | "PER2 is a key mammalian circadian clock protein. It also has a tumor suppressive function. Down regulation of PER2 in the cultured cancer cells accelerates cell proliferation, while overexpression of PER2 inhibits cell growth and induces apoptosis. The Per2 mutant mice have a cancer prone phenotype and an altered DNA damage response. Here we report that PER2 regulates AKT activity. Cells with down-regulated PER2 expression have prolonged high levels of AKT T308 phosphorylation after growth factor stimulation or DNA damage. PER2 down-regulation delays DNA damage induced Chk2 activation and overrides DNA damage induced apoptosis and cell cycle arrest."xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.org/dc/terms/identifier | "doi:10.1139/o2012-025"xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/author | "Jabbari E."xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/name | "Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/pages | "675-682"xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/title | "Mammalian PER2 regulates AKT activation and DNA damage response."xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/22905719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22905719 |
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