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http://purl.uniprot.org/citations/22905766http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome. We aimed to investigate the clinical significance of GOLPH3 expression in the development and progression of clinically N0 (cN0) oral tongue cancer.

Methods

Real-time PCR and Western blotting analyses were employed to examine GOLPH3 expression in four oral tongue cancer cell lines, primary cultured normal tongue epithelial cells (TEC), eight matched pairs of oral tongue cancer samples and adjacent noncancerous tissue samples from the same patient. Immunohistochemistry (IHC) was performed to examine GOLPH3 protein expression in paraffin-embedded tissues from 179 cN0 oral tongue cancer patients. Statistical analyses were applied to evaluate the diagnostic value and the associations of GOLPH3 expression with clinical parameters.

Results

GOLPH3 mRNA and protein was up-regulated in oral tongue cancer cell lines and cancerous tissues compared with that in primary cultured normal tongue epithelial cells (TEC) and adjacent noncancerous tissue samples. GOLPH3 protein level was positively correlated with clinical stage (P = 0.001), T classification (P = 0.001), N classification (P = 0.043) and recurrence (P = 0.009). Patients with higher GOLPH3 expression had shorter overall survival time, whereas those with lower GOLPH3 expression had longer survival time.

Conclusion

Our results suggest GOLPH3 overexpression is associated with poor prognosis for cN0 oral tongue cancer patients and may represent a novel and useful prognostic indicator for cN0 oral tongue cancer."xsd:string
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http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Chen S.W."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Guo L."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Song M."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Zhao X.H."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Wang L.P."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Zhuang S.M."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/author"Song L.B."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/name"J Transl Med"xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/pages"168"xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/title"GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer."xsd:string
http://purl.uniprot.org/citations/22905766http://purl.uniprot.org/core/volume"10"xsd:string
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