| http://purl.uniprot.org/citations/22909346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22909346 | http://www.w3.org/2000/01/rdf-schema#comment | "The Scar (suppressor of cAMP receptor)/WAVE [WASP (Wiskott-Aldrich syndrome protein) verprolin homologous] complex plays a major role in the motility of cells by activating the Arp2/3 complex, which initiates actin branching and drives protrusions. Mammals have three Scar/WAVE isoforms, which show some tissue-specific expression, but their functions have not been differentiated. In the present study we show that depletion of Scar/WAVE3Â in the mammalian breast cancer cells MDA-MB-231 results in larger and less dynamic lamellipodia. Scar/WAVE3-depleted cells move more slowly but more persistently on a two-dimensional matrix and they typically only show one lamellipod. However, Scar/WAVE3 appears to have no role in driving invasiveness in a three-dimensional Matrigelâ„¢ invasion assay or a three-dimensional collagen invasion assay, suggesting that lamellipodial persistence as seen in two-dimensions is not crucial in three-dimensional environments."xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20112206"xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/author | "Insall R.H."xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/author | "Timpson P."xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/author | "Machesky L.M."xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/author | "Spence H.J."xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/author | "Tang H.R."xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/pages | "35-42"xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/title | "Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions."xsd:string |
| http://purl.uniprot.org/citations/22909346 | http://purl.uniprot.org/core/volume | "448"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B4DGR1-mappedCitation-22909346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22909346 |
| http://purl.uniprot.org/uniprot/#_Q5T8P4-mappedCitation-22909346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22909346 |
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| http://purl.uniprot.org/uniprot/Q9UPY6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22909346 |
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