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| http://purl.uniprot.org/citations/22910694 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of members of the B7 superfamily of ligands have been implicated in tumor immunogenicity and cancer development. Two of these recently characterized ligands, B7-H4 and B7-H3, have been linked to ovarian tumors. B7-H4 is consistently overexpressed in ovarian tumor specimens, and its tissue and serum levels have been found to be a potential biomarker for ovarian cancer, either alone or in combination with CA125. More recently, B7-H3 has been found to be overexpressed in a large series of ovarian cancer tumor specimens and similar to other types of carcinomas, B7-H3 overexpression has been correlated with poor survival. On the basis of the results obtained by knocking down B7-H3 protein using siRNA, researchers have suggested that blocking the action of B7-H3 could reduce tumor growth, metastatic potential, and improve survival. Because siRNA knock-down is not an ideal clinical therapeutic vehicle, additional studies using antibody-mediated suppression of the B7-H3 protein are necessary to fully evaluate the clinical potential of this molecule as a therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ygyno.2012.08.017"xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/author | "Ferrone S."xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/author | "Straughn J.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/author | "Buchsbaum D.J."xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/author | "Fauci J.M."xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/name | "Gynecol Oncol"xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/pages | "420-425"xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/title | "A review of B7-H3 and B7-H4 immune molecules and their role in ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/22910694 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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