| http://purl.uniprot.org/citations/22911824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22911824 | http://www.w3.org/2000/01/rdf-schema#comment | "The Fra-1/AP-1 transcription factor plays a key role in tumor epithelial cell progression; however, its role in pathogenic lung fibrosis remains unclear. In the present study, using a genetic approach (Fra-1 deficient mice), we have demonstrated a novel regulatory (protective) role for Fra-1 in lung fibrosis. We found greater levels of progressive interstitial fibrosis, characterized by increased levels of inflammation, collagen accumulation, and profibrotic and fibrotic gene expression in the lungs of Fra-1(Δ/Δ) mice than in those of Fra-1(+/+) mice following bleomycin treatment. Fra-1 knockdown in human lung epithelial cells caused the upregulation of mesenchymal marker N-cadherin, concomitant with a downregulation of the epithelial phenotype marker E-cadherin, under basal conditions and in response to bleomycin and TGF-β1. Furthermore, Fra-1 knockdown caused an enhanced expression of type 1 collagen and the downregulation of collagenase (MMP-1 and MMP-13) gene expression in human lung epithelial cells. Collectively, our findings demonstrate that Fra-1 mediates anti-fibrotic effects in the lung through the modulation of proinflammatory, profibrotic and fibrotic gene expression, and suggests that the Fra-1 transcription factor may be a potential target for pulmonary fibrosis, a progressive disorder with poor prognosis and treatment."xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0041611"xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/author | "Reddy S.P."xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/author | "Rajasekaran S."xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/author | "Vaz M."xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/pages | "e41611"xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/title | "Fra-1/AP-1 transcription factor negatively regulates pulmonary fibrosis in vivo."xsd:string |
| http://purl.uniprot.org/citations/22911824 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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