| http://purl.uniprot.org/citations/22911848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22911848 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine critical host factors involved in HIV-1 replication, a dominant effector genetics approach was developed to reveal signaling pathways on which HIV-1 depends for replication. A large library of short peptide aptamers was expressed via retroviral delivery in T cells. Peptides that interfered with T cell activation-dependent processes that might support HIV-1 replication were identified. One of the selected peptides altered signaling, lead to a difference in T cell activation status, and inhibited HIV-1 replication. The target of the peptide was JAB1/CSN5, a component of the signalosome complex. JAB1 expression overcame the inhibition of HIV-1 replication in the presence of peptide and also promoted HIV-1 replication in activated primary CD4(+) T cells. This peptide blocked physiological release of JAB1 from the accessory T cell surface protein LFA-1, downstream AP-1 dependent events, NFAT activation, and HIV-1 replication. Thus, genetic selection for intracellular aptamer inhibitors of host cell processes proximal to signals at the immunological synapse of T cells can define unique mechanisms important to HIV-1 replication."xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0041725"xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/author | "Nolan G.P."xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/author | "Krutzik P.O."xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/author | "Kinoshita S.M."xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/pages | "e41725"xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/title | "COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication."xsd:string |
| http://purl.uniprot.org/citations/22911848 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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