| http://purl.uniprot.org/citations/22912596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22912596 | http://www.w3.org/2000/01/rdf-schema#comment | "dMi-2 is a highly conserved ATP-dependent chromatin-remodeling factor that regulates transcription and cell fates by altering the structure or positioning of nucleosomes. Here we report an unanticipated role for dMi-2 in the regulation of higher-order chromatin structure in Drosophila. Loss of dMi-2 function causes salivary gland polytene chromosomes to lose their characteristic banding pattern and appear more condensed than normal. Conversely, increased expression of dMi-2 triggers decondensation of polytene chromosomes accompanied by a significant increase in nuclear volume; this effect is relatively rapid and is dependent on the ATPase activity of dMi-2. Live analysis revealed that dMi-2 disrupts interactions between the aligned chromatids of salivary gland polytene chromosomes. dMi-2 and the cohesin complex are enriched at sites of active transcription; fluorescence-recovery after photobleaching (FRAP) assays showed that dMi-2 decreases stable association of cohesin with polytene chromosomes. These findings demonstrate that dMi-2 is an important regulator of both chromosome condensation and cohesin binding in interphase cells."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002878"xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Dorsett D."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Fasulo B."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Tamkun J.W."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Brehm A."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Deuring R."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Murawska M."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Gause M."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Dorighi K.M."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/author | "Schaaf C.A."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/pages | "e1002878"xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/title | "The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo."xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/22912596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22912596 |
| http://purl.uniprot.org/citations/22912596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22912596 |
| http://purl.uniprot.org/uniprot/O97159#attribution-65E9C5934BC5EDF378760E0C22E40478 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22912596 |
| http://purl.uniprot.org/uniprot/O97159#attribution-8C674C28E5905CEE4D14B9DC3695215A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22912596 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF23-mappedCitation-22912596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22912596 |
| http://purl.uniprot.org/uniprot/#_A0A021WW32-mappedCitation-22912596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22912596 |
| http://purl.uniprot.org/uniprot/#_E1JGX3-mappedCitation-22912596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22912596 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGZ0-mappedCitation-22912596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22912596 |