| http://purl.uniprot.org/citations/22916009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22916009 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic viral infections lead to persistent CD8 T cell activation and functional exhaustion. Expression of programmed cell death-1 (PD-1) has been associated to CD8 T cell dysfunction in HIV infection. Herein we report that another negative regulator of T cell activation, CD160, was also upregulated on HIV-specific CD8 T lymphocytes mostly during the chronic phase of infection. CD8 T cells that expressed CD160 or PD-1 were still functional whereas co-expression of CD160 and PD-1 on CD8 T cells defined a novel subset with all the characteristics of functionally exhausted T cells. Blocking the interaction of CD160 with HVEM, its natural ligand, increased HIV-specific CD8 T cell proliferation and cytokine production. Transcriptional profiling showed that CD160(-)PD-1(+)CD8 T cells encompassed a subset of CD8(+) T cells with activated transcriptional programs, while CD160(+)PD-1(+) T cells encompassed primarily CD8(+) T cells with an exhausted phenotype. The transcriptional profile of CD160(+)PD-1(+) T cells showed the downregulation of the NFκB transcriptional node and the upregulation of several inhibitors of T cell survival and function. Overall, we show that CD160 and PD-1 expressing subsets allow differentiating between activated and exhausted CD8 T cells further reinforcing the notion that restoration of function will require multipronged approaches that target several negative regulators."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1002840"xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "He Z."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Tremblay C."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Sekaly R.P."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Routy J.P."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Bernard N."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Boulassel M.R."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "El-Far M."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Haddad E.K."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Yassine-Diab B."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Peretz Y."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Dupuy F.P."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Balderas R."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Goulet J.P."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Filali-Mouhim A."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Loubert J.B."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/author | "Bordi R."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/pages | "e1002840"xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/title | "CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction."xsd:string |
| http://purl.uniprot.org/citations/22916009 | http://purl.uniprot.org/core/volume | "8"xsd:string |