| http://purl.uniprot.org/citations/22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22920254 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial abnormalities have been documented in Alzheimer's disease and related neurodegenerative disorders, but the causal relationship between mitochondrial changes and neurodegeneration, and the specific mechanisms promoting mitochondrial dysfunction, are unclear. Here, we find that expression of human tau results in elongation of mitochondria in both Drosophila and mouse neurons. Elongation is accompanied by mitochondrial dysfunction and cell cycle-mediated cell death, which can be rescued in vivo by genetically restoring the proper balance of mitochondrial fission and fusion. We have previously demonstrated that stabilization of actin by tau is critical for neurotoxicity of the protein. Here, we demonstrate a conserved role for actin and myosin in regulating mitochondrial fission and show that excess actin stabilization inhibits association of the fission protein DRP1 with mitochondria, leading to mitochondrial elongation and subsequent neurotoxicity. Our results thus identify actin-mediated disruption of mitochondrial dynamics as a direct mechanism of tau toxicity in neurons in vivo."xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2012.06.026"xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/author | "Feany M.B."xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/author | "Gotz J."xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/author | "DuBoff B."xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/pages | "618-632"xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/title | "Tau promotes neurodegeneration via DRP1 mislocalization in vivo."xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/22920254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22920254 |
| http://purl.uniprot.org/citations/22920254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22920254 |
| http://purl.uniprot.org/uniprot/P10636#attribution-15EA0BB93E87B254A5134D02F06A2186 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/P10636#attribution-73E764D33C85EDA1749B6DAB8ACC9217 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/P10636#attribution-F77C9236798A15B6FCA5799EB32F84E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHG2-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHG6-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF33-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFB8-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGW0-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD95-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J3Z9-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD57-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7Q4-mappedCitation-22920254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22920254 |