| http://purl.uniprot.org/citations/22921914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22921914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22921914 | http://www.w3.org/2000/01/rdf-schema#comment | "In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOMA-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a "flip flop" that constrains asymmetric cell division to the stem cell region."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.07.017"xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.07.017"xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Bako L."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Bako L."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Long Y."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Long Y."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Dhonukshe P."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Dhonukshe P."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Murray J.A."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Murray J.A."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Scheres B."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Scheres B."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Benfey P.N."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Benfey P.N."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Mahonen A.P."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Mahonen A.P."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Diaz-Trivino S."xsd:string |
| http://purl.uniprot.org/citations/22921914 | http://purl.uniprot.org/core/author | "Diaz-Trivino S."xsd:string |