| http://purl.uniprot.org/citations/22922783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22922783 | http://www.w3.org/2000/01/rdf-schema#comment | "Auxiliary subunits regulate the trafficking, localization or gating kinetics of voltage- and ligand-gated ion channels by associating tightly and specifically with pore-forming subunits. However, no auxiliary subunits have been identified for members of the Cys-loop receptor superfamily. Here we identify MOLO-1, a positive regulator of levamisole-sensitive acetylcholine receptors (L-AChRs) at the Caenorhabditis elegans neuromuscular junction. MOLO-1 is a one-pass transmembrane protein that contains a single extracellular globular domain-the TPM domain, found in bacteria, plants and invertebrates, including nonvertebrate chordates. Loss of MOLO-1 impairs locomotion and renders worms resistant to the anthelmintic drug levamisole. In molo-1 mutants, L-AChR-dependent synaptic transmission is reduced by half, while the number and localization of receptors at synapses remain unchanged. In a heterologous expression system, MOLO-1 physically interacts with L-AChRs and directly enhances channel gating without affecting unitary conductance. The identification of MOLO-1 expands the mechanisms for generating functional and pharmacological diversity in the Cys-loop superfamily."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3197"xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/author | "Bessereau J.L."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/author | "Boulin T."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/author | "Rapti G."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/author | "Richmond J.E."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/author | "Stigloher C."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/author | "Briseno-Roa L."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/author | "Paoletti P."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/pages | "1374-1381"xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/title | "Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit."xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/22922783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22922783 |
| http://purl.uniprot.org/citations/22922783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22922783 |
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