| http://purl.uniprot.org/citations/22923583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22923583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22923583 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells. Blocking glycosylation of PFK1 at serine 529 reduced cancer cell proliferation in vitro and impaired tumor formation in vivo. These studies reveal a previously uncharacterized mechanism for the regulation of metabolic pathways in cancer and a possible target for therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1222278"xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1222278"xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Hill C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Hill C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Yi W."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Yi W."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Peters E.C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Peters E.C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Hsieh-Wilson L.C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Hsieh-Wilson L.C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Driggers E.M."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Driggers E.M."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Keenan M.C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Keenan M.C."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Mason D.E."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Mason D.E."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Clark P.M."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Clark P.M."xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Goddard W.A. III"xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/author | "Goddard W.A. III"xsd:string |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22923583 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |