| http://purl.uniprot.org/citations/22927415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22927415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22927415 | http://www.w3.org/2000/01/rdf-schema#comment | "Nectins are members of the Ig superfamily that mediate cell-cell adhesion through homophilic and heterophilic interactions. We have determined the crystal structure of the nectin-2 homodimer at 1.3 Å resolution. Structural analysis and complementary mutagenesis studies reveal the basis for recognition and selectivity among the nectin family members. Notably, the close proximity of charged residues at the dimer interface is a major determinant of the binding affinities associated with homophilic and heterophilic interactions within the nectin family. Our structural and biochemical data provide a mechanistic basis to explain stronger heterophilic versus weaker homophilic interactions among these family members and also offer insights into nectin-mediated transinteractions between engaging cells."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1212912109"xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1212912109"xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Almo S.C."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Almo S.C."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Ramagopal U.A."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Ramagopal U.A."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Vigdorovich V."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Vigdorovich V."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Nathenson S.G."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Nathenson S.G."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Rubinstein R."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Rubinstein R."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Samanta D."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/author | "Samanta D."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/pages | "14836-14840"xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/pages | "14836-14840"xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/title | "Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/22927415 | http://purl.uniprot.org/core/title | "Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion."xsd:string |