| http://purl.uniprot.org/citations/22927794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22927794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22927794 | http://www.w3.org/2000/01/rdf-schema#comment | "Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase I in C. elegans, yet the mechanism and scope of LAB-1 function remained unknown. Here we identify an unexpected earlier role for LAB-1 in promoting the establishment of sister chromatid cohesion in prophase I. LAB-1 and REC-8 are both required for the chromosomal association of the cohesin complex subunit SMC-3. Depletion of lab-1 results in partial loss of sister chromatid cohesion in rec-8 and coh-4 coh-3 mutants and further enhanced chromatid dissociation in worms where all three kleisins are mutated. Moreover, lab-1 depletion results in increased Aurora B kinase (AIR-2) signals in early prophase I nuclei, coupled with a parallel decrease in signals for the PP1 homolog, GSP-2. Finally, LAB-1 directly interacts with GSP-1 and GSP-2. We propose that LAB-1 targets the PP1 homologs to the chromatin at the onset of meiosis I, thereby antagonizing AIR-2 and cooperating with the cohesin complex to promote sister chromatid association and normal progression of the meiotic program."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.1001378"xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.1001378"xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Egydio de Carvalho C."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Egydio de Carvalho C."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Cheeseman I.M."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Cheeseman I.M."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Chu D.S."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Chu D.S."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Colaiacovo M.P."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Colaiacovo M.P."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Nadarajan S."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Nadarajan S."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Tzur Y.B."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Tzur Y.B."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Van Bostelen I."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/author | "Van Bostelen I."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/name | "PLoS Biol."xsd:string |
| http://purl.uniprot.org/citations/22927794 | http://purl.uniprot.org/core/name | "PLoS Biol."xsd:string |