| http://purl.uniprot.org/citations/22930730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22930730 | http://www.w3.org/2000/01/rdf-schema#comment | "Ewing sarcoma is a rare but aggressive disease most common in young adults. This cancer is driven by a unique chimeric fusion oncogene but targeted strategies have been elusive. Here we report the identification of the protein kinase PKC-ß (PRKCB) as a disease-specific druggable target for treatment of Ewing sarcoma. We found that transcriptional activation of PRKCB was directly regulated by the chimeric fusion oncogene EWSR1-FLI1 that drives this cancer. PRKCB phosphorylated histone H3T6 to permit global maintenance of H3K4 trimethylation at a variety of gene promoters. PRKCB loss induced apoptosis in vitro and prevented tumor growth in vivo. Gene expression profiling revealed a strong overlap between genes modulated by EWSR1-FLI1 and PRKCB in regulating crucial signaling pathways. Taken together, our findings offer a preclinical proof-of-concept for PRKCB as a promising therapeutic target in Ewing sarcoma."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-12-0371"xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Pierron G."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Delattre O."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Tirode F."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Ballet S."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Lamoureux F."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Redini F."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Han Z.Y."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Perrin V."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Decouvelaere A.V."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Geoerger B."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "de Pinieux G."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Benetkiewicz M."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Daudigeos-Dubus E."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/author | "Surdez D."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/pages | "4494-4503"xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/title | "Targeting the EWSR1-FLI1 oncogene-induced protein kinase PKC-beta abolishes ewing sarcoma growth."xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/22930730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22930730 |
| http://purl.uniprot.org/citations/22930730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22930730 |
| http://purl.uniprot.org/uniprot/#_A9Z0R7-mappedCitation-22930730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22930730 |