| http://purl.uniprot.org/citations/22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22933631 | http://www.w3.org/2000/01/rdf-schema#comment | "Work over the last decades has led to the identification of the factors that influence the survival and homeostasis of conventional T cells. IL-7 and TCR signaling promote the survival of naive CD4(+) and CD8(+) T cells in lymphoreplete mice and their proliferation in a lymphopenic environment, whereas survival and homeostatic proliferation of memory CD4(+) and CD8(+) T cells crucially depend on a combination of IL-7 and IL-15. In contrast, there is little information regarding the factors driving the proliferation of regulatory CD4(+) T cells in response to lymphopenia. In this study, we investigated whether regulatory CD4(+) T cell proliferation in response to lymphopenia was guided by classical homeostatic resources, such as IL-2, IL-7, or TCR-MHC interactions. Altogether, our data suggest that, although homeostatic proliferation of conventional naive CD4(+) T cells is closely related to IL-7 levels, the proliferation of regulatory CD4(+) T cells in response to lymphopenia appears to be primarily controlled by IL-2. The capacity of IL-7 to augment conventional T cell proliferation with minimal concomitant regulatory T cell expansion may be clinically exploitable in the treatment of patients with lymphopenia, especially in the case of chronic viral diseases or cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1103152"xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/author | "Stouvenel L."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/author | "Martin B."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/author | "Auffray C."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/author | "Lucas B."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/author | "Le Campion A."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/author | "Pommier A."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/author | "Delpoux A."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/pages | "3339-3346"xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/title | "IL-2 and IL-7 determine the homeostatic balance between the regulatory and conventional CD4+ T cell compartments during peripheral T cell reconstitution."xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/22933631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22933631 |
| http://purl.uniprot.org/citations/22933631 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22933631 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |
| http://purl.uniprot.org/uniprot/#_A6H6M1-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRC2-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4L2R0-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |
| http://purl.uniprot.org/uniprot/#_B0LAX5-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |
| http://purl.uniprot.org/uniprot/#_P10168-mappedCitation-22933631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22933631 |