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http://purl.uniprot.org/citations/22934063http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22934063http://www.w3.org/2000/01/rdf-schema#comment"

Objective

We have previously shown that the transcription factor, nuclear factor of activated T-cells 5 (NFAT5), regulates vascular smooth muscle cell phenotypic modulation, but the role of NFAT5 in atherosclerosis is unknown. Our main objective was to determine if NFAT5 expression in bone marrow (BM)-derived cells altered atherosclerotic development and macrophage function.

Methods and results

NFAT5(+/-)ApoE(-/-) mice were generated for in vivo atherosclerosis studies. Following high fat diet feeding, en face analysis of the thoracic aorta established that genome-wide NFAT5 haploinsufficiency reduced atherosclerotic lesion formation by 73%. BM transplant studies revealed that transplantation of NFAT5(+/-)ApoE(-/-) marrow into NFAT5(+/+)ApoE(-/-) mice resulted in a similar 86% reduction in lesion formation. In vitro functional analysis of BM-derived macrophages demonstrated that NFAT5 is required for macrophage migration, which is a key event in the propagation of atherosclerosis.

Conclusion

We have identified NFAT5 in BM-derived cells as a positive regulator of atherosclerotic lesion formation and macrophage function in the vasculature."xsd:string
http://purl.uniprot.org/citations/22934063http://purl.org/dc/terms/identifier"doi:10.3389/fphys.2012.00313"xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/author"Kwon H.M."xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/author"Wamhoff B.R."xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/author"Leitinger N."xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/author"Halterman J.A."xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/name"Front Physiol"xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/pages"313"xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/title"NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration."xsd:string
http://purl.uniprot.org/citations/22934063http://purl.uniprot.org/core/volume"3"xsd:string
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