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http://purl.uniprot.org/citations/22936257http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22936257http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Preeclampsia is a specific pregnancy disorder which could be due, at least in part, to impaired invasion of trophoblastic cells. Since matrix metalloproteinases (MMPs) are the predominant proteases involved in trophoblastic invasion, we investigated and compared expression of MMP-1, 2, 7, 9 and 12 of cytotrophoblastic cells (CTB) purified from preeclamptic (PE) placentas to control CTB.

Material and methods

In order to evaluate invasive properties of cells, purified CTB were seeded on collagen-coated insert following boyden chamber principle and matrix metalloproteinases (MMPs) expression was evaluated by qPCR.

Results

Our results showed that PE CTB are less invasive than control CTB in vitro. In parallel, expression of MMPs, except for MMP-2, tends to be decreased in PE CTB compared to control CTB.

Conclusion

At the exception of MMP-2, this study confirms the importance of MMPs in development of PE."xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/author"Cohen M."xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/author"Ribaux P."xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/author"Irion O."xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/author"Epiney M."xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/name"Neuro Endocrinol Lett"xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/pages"406-411"xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/title"Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas."xsd:string
http://purl.uniprot.org/citations/22936257http://purl.uniprot.org/core/volume"33"xsd:string
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