| http://purl.uniprot.org/citations/22936657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22936657 | http://www.w3.org/2000/01/rdf-schema#comment | "BLT1 is a high-affinity receptor for leukotriene B4 (LTB4) that is a potent lipid chemoattractant for myeloid leukocytes. The role of LTB4/BLT1 axis in tumor immunology, including cytokine-based tumor vaccine, however, remains unknown. We here demonstrated that BLT1-deficient mice rejected subcutaneous tumor challenge of GM-CSF gene-transduced WEHI3B (WGM) leukemia cells (KO/WGM) and elicited robust antitumor responses against second tumor challenge with WEHI3B cells. During GM-CSF-induced tumor regression, the defective LTB4/BLT1 signaling significantly reduced tumor-infiltrating myeloid-derived suppressor cells, increased the maturation status of dendritic cells in tumor tissues, enhanced their CD4(+) T-cell stimulation capacity and migration rate of dendritic cells that had phagocytosed tumor-associated antigens into tumor-draining lymph nodes, suggesting a positive impact on GM-CSF-sensitized innate immunity. Furthermore, KO/WGM mice displayed activated adaptive immunity by attenuating regulatory CD4(+) T subsets and increasing numbers of Th17 and memory CD44(hi)CD4(+) T subsets, both of which elicited superior antitumor effects as evidenced by adoptive cell transfer. In vivo depletion assays also revealed that CD4(+) T cells were the main effectors of the persistent antitumor immunity. Our data collectively underscore a negative role of LTB4/BLT1 signaling in effective generation and maintenance of GM-CSF-induced antitumor memory CD4(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-10-383240"xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Inoue H."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Nakanishi Y."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Watanabe A."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Takayama K."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Sasaki F."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Matsumura Y."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Tani K."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Yokota Y."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Sakamoto C."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Yokomizo T."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Nabeta H."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Narusawa M."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Hijikata Y."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/author | "Iga-Murahashi M."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/pages | "3444-3454"xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/title | "Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems."xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/22936657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22936657 |
| http://purl.uniprot.org/citations/22936657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22936657 |
| http://purl.uniprot.org/uniprot/#_D3Z2B2-mappedCitation-22936657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22936657 |