| http://purl.uniprot.org/citations/22936801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22936801 | http://www.w3.org/2000/01/rdf-schema#comment | "Estrogen promotes growth in many tissues by activating Wnt/β-catenin signaling. Recently, ASPP 049, a diarylheptanoid isolated from Curcuma comosa Roxb., has been identified as a phytoestrogen. This investigation determined the involvement of Wnt/β-catenin signaling in the estrogenic activity of this diarylheptanoid in transfected HEK 293T and in mouse preosteoblastic (MC3T3-E1) cells using a TOPflash luciferase assay and immunofluorescence. ASPP 049 rapidly activated T-cell-specific transcription factor/lymphoid enhancer binding factor-mediated transcription activity and induced β-catenin accumulation in the nucleus. Interestingly, the effects of ASPP 049 on the transcriptional activity and induction and accumulation of β-catenin protein in the nucleus of MC3T3-E1 cells were greater compared with estradiol. Activation of β-catenin in MC3T3-E1 cells was inhibited by ICI 182,780, suggesting that an estrogen receptor is required. In addition, ASPP 049 induced phosphorylations at serine 473 of Akt and serine 9 of GSK-3β. Moreover, ASPP 049 also induced proliferation and expressions of Wnt target genes Axin2 and Runx2 in MC3T3-E1 cells. In addition, ASPP 049 increased alkaline phosphatase expression, and activity that was abolished by DKK-1, a blocker of the Wnt/β-catenin receptor. Taken together, these results suggest that ASPP 049 from C. comosa induced osteoblastic cell proliferation and differentiation through ERα-, Akt-, and GSK-3β-dependent activation of β-catenin signaling. Our findings provide a scientific rationale for using C. comosa as a dietary supplement to prevent bone loss in postmenopausal women."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.344747"xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Chairoungdua A."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Piyachaturawat P."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Suksamrarn A."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Thongon N."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Bhukhai K."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Bhummaphan N."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Janjorn K."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Suksen K."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/author | "Tantikanlayaporn D."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/pages | "36168-36178"xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/title | "A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3beta protein-dependent activation of the Wnt/beta-catenin signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/22936801 | http://purl.uniprot.org/core/volume | "287"xsd:string |
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