| http://purl.uniprot.org/citations/22938469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22938469 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated whether IFN-β inhibits the growth of human malignant glioma and induces glioma cell apoptosis using the human IFN-β gene transfected into glioma cells. A eukaryonic expression vector (pSV2IFNβ) for IFN-β was transfected into the glioma cell line SHG44 using liposome transfection. Stable transfection and IFN-β expression were confirmed using an enzyme-linked immunosorbent assay (ELISA). Cell apoptosis was also assessed by Hoechst staining and electron microscopy. In vivo experiments were used to establish a SHG44 glioma model in nude mice. Liposomes containing the human IFN-β gene were injected into the SHG44 glioma of nude mice to observe glioma growth and calculate tumor size. Fas expression was evaluated using immunohistochemistry. The IFN-β gene was successfully transfected and expressed in the SHG44 glioma cells in vitro. A significant difference in the number of apoptotic cells was observed between transfected and non-transfected cells. Glioma growth in nude mice was inhibited in vivo, with significant induction of apoptosis. Fas expression was also elevated. The IFN-β gene induces apoptosis in glioma cells, possibly through upregulation of Fas. The IFN-β gene modulation in the Fas pathway and apoptosis in glioma cells may be important for the treatment of gliomas."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.org/dc/terms/identifier | "doi:10.7314/apjcp.2012.13.6.2837"xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Gao W.W."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Tian H.L."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Cheng S.W."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Cao H.L."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/author | "Ju S.M."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/name | "Asian Pac J Cancer Prev"xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/pages | "2837-2840"xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/title | "Induction of apoptosis in glioma cells and upregulation of Fas expression using the human interferon-beta gene."xsd:string |
| http://purl.uniprot.org/citations/22938469 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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