| http://purl.uniprot.org/citations/22939628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22939628 | http://www.w3.org/2000/01/rdf-schema#comment | "The type 2 ryanodine receptor/calcium release channel (RyR2), required for excitation-contraction coupling in the heart, is abundant in the brain. Chronic stress induces catecholamine biosynthesis and release, stimulating β-adrenergic receptors and activating cAMP signaling pathways in neurons. In a murine chronic restraint stress model, neuronal RyR2 were phosphorylated by protein kinase A (PKA), oxidized, and nitrosylated, resulting in depletion of the stabilizing subunit calstabin2 (FKBP12.6) from the channel complex and intracellular calcium leak. Stress-induced cognitive dysfunction, including deficits in learning and memory, and reduced long-term potentiation (LTP) at the hippocampal CA3-CA1 connection were rescued by oral administration of S107, a compound developed in our laboratory that stabilizes RyR2-calstabin2 interaction, or by genetic ablation of the RyR2 PKA phosphorylation site at serine 2808. Thus, neuronal RyR2 remodeling contributes to stress-induced cognitive dysfunction. Leaky RyR2 could be a therapeutic target for treatment of stress-induced cognitive dysfunction."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.06.052"xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Xie W."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Meli A.C."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Marks A.R."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Reiken S."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Chen B.X."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Arancio O."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/author | "Betzenhauser M.J."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/pages | "1055-1067"xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/title | "Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction."xsd:string |
| http://purl.uniprot.org/citations/22939628 | http://purl.uniprot.org/core/volume | "150"xsd:string |
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