| http://purl.uniprot.org/citations/22940583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22940583 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasma membrane repair involves the coordinated effort of proteins and the inner phospholipid surface to mend the rupture and return the cell back to homeostasis. Here, we present the three-dimensional structure of a multiprotein complex that includes S100A10, annexin A2, and AHNAK, which along with dysferlin, functions in muscle and cardiac tissue repair. The 3.5 Å resolution X-ray structure shows that a single region from the AHNAK C terminus is recruited by an S100A10-annexin A2 heterotetramer, forming an asymmetric ternary complex. The AHNAK peptide adopts a coil conformation that arches across the heterotetramer contacting both annexin A2 and S100A10 protomers with tight affinity (∼30 nM) and establishing a structural rationale whereby both S100A10 and annexin proteins are needed in AHNAK recruitment. The structure evokes a model whereby AHNAK is targeted to the membrane surface through sandwiching of the binding region between the S100A10/annexin A2 complex and the phospholipid membrane."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2012.08.004"xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/author | "Lee T.W."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/author | "Shaw G.S."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/author | "Junop M.S."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/author | "Barber K.R."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/author | "Rezvanpour A."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/author | "Dempsey B.R."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/pages | "1737-1745"xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/title | "Structure of an asymmetric ternary protein complex provides insight for membrane interaction."xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/22940583 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22940583 |
| http://purl.uniprot.org/citations/22940583 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22940583 |
| http://purl.uniprot.org/uniprot/Q09666#attribution-6DBE8960A94CDAC996FF48EBF3A00C5F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/P07356#attribution-6DBE8960A94CDAC996FF48EBF3A00C5F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/P07355#attribution-6DBE8960A94CDAC996FF48EBF3A00C5F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/P60903#attribution-6DBE8960A94CDAC996FF48EBF3A00C5F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/P08207#attribution-6DBE8960A94CDAC996FF48EBF3A00C5F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/E9Q616#attribution-6DBE8960A94CDAC996FF48EBF3A00C5F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/#_A0A024R5Z7-mappedCitation-22940583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/#_E9Q616-mappedCitation-22940583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22940583 |
| http://purl.uniprot.org/uniprot/#_A0A494B8Y7-mappedCitation-22940583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22940583 |