| http://purl.uniprot.org/citations/22941246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22941246 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Here we report a unique lymphoid-primed population in human bone marrow that was generated from hematopoietic stem cells (HSCs) before onset of the expression of CD10 and commitment to the B cell lineage. We identified this subset by high expression of the homing molecule L-selectin (CD62L). CD10(-)CD62L(hi) progenitors had full lymphoid and monocytic potential but lacked erythroid potential. Gene-expression profiling placed the CD10(-)CD62L(hi) population at an intermediate stage of differentiation between HSCs and lineage-negative (Lin(-)) CD34(+)CD10(+) progenitors. CD62L was expressed on immature thymocytes, and its ligands were expressed at the cortico-medullary junction of the thymus, which suggested a possible role for this molecule in homing to the thymus. Our studies identify the earliest stage of lymphoid priming in human bone marrow."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2405"xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Mikkola H.K."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Ge S."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Crooks G.M."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Hao Q.L."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Sasidharan R."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Kohn L.A."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/author | "Parekh C."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/pages | "963-971"xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/title | "Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin."xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22941246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22941246 |
| http://purl.uniprot.org/citations/22941246 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22941246 |
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| http://purl.uniprot.org/uniprot/#_B4DQA0-mappedCitation-22941246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22941246 |
| http://purl.uniprot.org/uniprot/#_Q6ULR8-mappedCitation-22941246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22941246 |
| http://purl.uniprot.org/uniprot/#_Q8WW79-mappedCitation-22941246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22941246 |
| http://purl.uniprot.org/uniprot/P14151 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22941246 |
| http://purl.uniprot.org/uniprot/Q6ULR8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22941246 |