| http://purl.uniprot.org/citations/22949502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22949502 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of the pre-B cell receptor (BCR) is confined to the early stage of B cell development, and its dysregulation is associated with anomalies of B-lineage cells, including leukemogenesis. Previous studies suggested that the pre-BCR signal might trigger the autonomous termination of pre-BCR expression even before the silencing of pre-BCR gene expression to prevent sustained pre-BCR expression. However, the underlying mechanism remains ill defined. Here we demonstrate that the pre-BCR signal induces the expression of lysosome-associated protein transmembrane 5 (LAPTM5), which leads to the prompt downmodulation of the pre-BCR. While LAPTM5 induction had no significant impact on the internalization of cell surface pre-BCR, it elicited the translocation of a large pool of intracellular pre-BCR from the endoplasmic reticulum to the lysosomal compartment concomitantly with a drastic reduction of the level of intracellular pre-BCR proteins. This reduction was inhibited by lysosomal inhibitors, indicating the lysosomal degradation of the pre-BCR. Notably, the LAPTM5 deficiency in pre-B cells led to the augmented expression level of surface pre-BCR. Collectively, the pre-BCR induces the prompt downmodulation of its own expression through the induction of LAPTM5, which promotes the lysosomal transport and degradation of the intracellular pre-BCR pool and, hence, limits the supply of pre-BCR to the cell surface."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00531-12"xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/author | "Wang J.Y."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/author | "Kawano Y."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/author | "Yoshikawa S."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/author | "Karasuyama H."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/author | "Kitamura D."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/author | "Ouchida R."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/pages | "4462-4471"xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/title | "A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5."xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22949502 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22949502 |
| http://purl.uniprot.org/citations/22949502 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22949502 |
| http://purl.uniprot.org/uniprot/Q9QUN3#attribution-346CB87488D33C12E497B03B39B3094D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22949502 |
| http://purl.uniprot.org/uniprot/Q61168#attribution-346CB87488D33C12E497B03B39B3094D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22949502 |
| http://purl.uniprot.org/uniprot/Q61168#attribution-8038D3763222E44F4D6CD695A42B29F8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22949502 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-22949502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22949502 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-22949502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22949502 |
| http://purl.uniprot.org/uniprot/#_D3YWR2-mappedCitation-22949502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22949502 |
| http://purl.uniprot.org/uniprot/#_B1ASF7-mappedCitation-22949502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22949502 |
| http://purl.uniprot.org/uniprot/#_B7ZMX3-mappedCitation-22949502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22949502 |