| http://purl.uniprot.org/citations/2295621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2295621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2295621 | http://www.w3.org/2000/01/rdf-schema#comment | "A new series of polypeptide presynaptic antagonists ("omega-agatoxins") was purified from venom of the funnel web spider Agelenopsis aperta. Physiological data indicate that all of these peptides are antagonists of voltage-sensitive calcium channels. Although all three omega-agatoxins (Aga) described here (omega-Aga-IA, omega-Aga-IB, and omega-Aga-IIA) block insect neuromuscular transmission presynaptically, biochemical data permit their subclassification as Type I and Type II toxins. Type I toxins (omega-Aga-IA and -IB) are 7.5 kDa, have closely related amino acid sequences, and exhibit characteristic tryptophan-like UV absorbance spectra. Complete Edman sequencing of omega-Aga-IA reveals it to be a 66-amino acid polypeptide containing 9 cysteines and 5 tryptophan residues. omega-Aga-IIA, a Type II toxin, is 11 kDa, shows limited amino acid sequence similarity to the Type I toxins, and exhibits mixed tryptophan- and tyrosine-like absorbance. Nanomolar concentrations of omega-Aga-IIA inhibit the specific binding of 125I-labeled omega-conotoxin GVIA to chick synaptosomal membranes while omega-Aga-IA and -IB have no effect under identical conditions. The omega-agatoxins thus are defined as two subtypes of neuronal calcium channel toxins with different structural characteristics and calcium channel binding specificities."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)40129-4"xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)40129-4"xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Adams M.E."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Adams M.E."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Venema V.J."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Venema V.J."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Bindokas V.P."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Bindokas V.P."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Hasegawa L."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/author | "Hasegawa L."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/pages | "861-867"xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/pages | "861-867"xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/title | "Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/title | "Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom."xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/volume | "265"xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://purl.uniprot.org/core/volume | "265"xsd:string |
| http://purl.uniprot.org/citations/2295621 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2295621 |
| http://purl.uniprot.org/citations/2295621 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2295621 |