| http://purl.uniprot.org/citations/22960268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22960268 | http://www.w3.org/2000/01/rdf-schema#comment | "Several cis-acting elements play critical roles in maintaining circadian expression of clock and clock-controlled genes. Using in silico analysis, we identified 10 sequence motifs that are correlated with the circadian phases of gene expression in the cartilage. One of these motifs, an E-box-like clock-related element (EL-box; GGCACGAGGC), can mediate BMAL1/CLOCK-induced transcription, which is typically regulated through an E-box or E'-box. Expression of EL-box-containing genes, including Ank, Dbp, and Nr1d1 (Rev-erbα), was induced by BMAL1/CLOCK or BMAL1/NPAS2. Compared with the E-box, the EL-box elements had distinct responsiveness to DEC1, DEC2, and HES1: suppressive actions of DEC1 and DEC2 on the EL-box were less potent than those on the E-box. HES1, which is known to bind to the N-box (CACNAG), suppressed enhancer activity of the EL-box, but not the E-box. In the Dbp promoter, an EL-box worked cooperatively with a noncanonical (NC) E-box to mediate BMAL1/CLOCK actions. These findings suggest that in addition to known clock elements, the EL-box element may contribute to circadian regulation of clock and clock-controlled genes."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2012.08.022"xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Kawamoto T."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Hashimoto S."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Nakao S."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Gotoh O."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Fujimoto K."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Noshiro M."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Honda K.K."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Ueshima T."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/author | "Ichinose N."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/pages | "118-125"xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/title | "Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES1."xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://purl.uniprot.org/core/volume | "510"xsd:string |
| http://purl.uniprot.org/citations/22960268 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22960268 |
| http://purl.uniprot.org/citations/22960268 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22960268 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K8N0-mappedCitation-22960268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22960268 |
| http://purl.uniprot.org/uniprot/#_D3ZT62-mappedCitation-22960268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22960268 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZXD2-mappedCitation-22960268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22960268 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A2N7-mappedCitation-22960268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22960268 |
| http://purl.uniprot.org/uniprot/#_A6I875-mappedCitation-22960268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22960268 |