| http://purl.uniprot.org/citations/22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22965115 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-E2-related factor 2 (Nrf2) is a key transcription factor that is critical for cellular defense against oxidative and xenobiotic insults. Nrf2 heterodimerizes with small Maf (sMaf) proteins and binds to antioxidant response elements (AREs) to activate a battery of cytoprotective genes. However, it remains unclear to what extent the Nrf2-sMaf heterodimers contribute to ARE-dependent gene regulation on a genome-wide scale. We performed chromatin immunoprecipitation coupled with high-throughput sequencing and identified the binding sites of Nrf2 and MafG throughout the genome. Compared to sites occupied by Nrf2 alone, many sites co-occupied by Nrf2 and MafG exhibit high enrichment and are located in species-conserved genomic regions. The ARE motifs were significantly enriched among the recovered Nrf2-MafG-binding sites but not among the Nrf2-binding sites that did not display MafG binding. The majority of the Nrf2-regulated cytoprotective genes were found in the vicinity of Nrf2-MafG-binding sites. Additionally, sequences that regulate glucose metabolism and several amino acid transporters were identified as Nrf2-MafG target genes, suggesting diverse roles for the Nrf2-MafG heterodimer in stress response. These data clearly support the notion that Nrf2-sMaf heterodimers are complexes that regulate batteries of genes involved in various aspects of cytoprotective and metabolic functions through associated AREs."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gks827"xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Nishida Y."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Engel J.D."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Nagashima T."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Funayama R."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Katsuoka F."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/author | "Hirotsu Y."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/pages | "10228-10239"xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/title | "Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks."xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/22965115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22965115 |
| http://purl.uniprot.org/citations/22965115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22965115 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHY0-mappedCitation-22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22965115 |
| http://purl.uniprot.org/uniprot/#_A0A1S6GWH7-mappedCitation-22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22965115 |
| http://purl.uniprot.org/uniprot/#_Q16236-mappedCitation-22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22965115 |
| http://purl.uniprot.org/uniprot/#_Q3U568-mappedCitation-22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22965115 |
| http://purl.uniprot.org/uniprot/#_Q3UKW6-mappedCitation-22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22965115 |
| http://purl.uniprot.org/uniprot/#_O54790-mappedCitation-22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22965115 |
| http://purl.uniprot.org/uniprot/#_O54791-mappedCitation-22965115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22965115 |