| http://purl.uniprot.org/citations/22973541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22973541 | http://www.w3.org/2000/01/rdf-schema#comment | "Alleles derived from skin tumor-resistant Car-R mice provide resistance to both skin and lung tumorigenesis over the susceptibility of the SWR/J strain. In an effort to map tumor modifier loci affecting both tumor types, we carried out a genetic linkage analysis in backcross SWR/J x (SWR/J x Car-R) mice and identified a locus (Lsktm1) on chromosome 1 linked to both skin (LOD score = 3.93) and lung (LOD score = 8.74) tumorigenesis. Two genes, Igfbp5 and Igfbp2, residing in this locus and belonging to the insulin-like growth factor binding protein family were expressed at significantly greater levels in normal lung tissue from cancer-resistant Car-R mice than in cancer-susceptible SWR/J mice. Overexpression of the recombinant Igfbp5 and Igfbp2 genes in two lung cancer cell lines significantly inhibited clonogenicity (P < 0.0001). Collectively, we have identified a single polymorphic locus that affects skin and lung tumorigenesis and identify Igfbp5 and Igfbp2 as candidate modifier genes of lung tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.112.003525"xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Dragani T.A."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Manenti G."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Colombo F."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Mancuso M."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Galvan A."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Broman K.W."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Pazzaglia S."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Saran A."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/author | "Noci S."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/pages | "1041-1046"xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/title | "The Lsktm1 locus modulates lung and skin tumorigenesis in the mouse."xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/22973541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22973541 |
| http://purl.uniprot.org/citations/22973541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22973541 |
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| http://purl.uniprot.org/uniprot/#_Q3UQV0-mappedCitation-22973541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22973541 |
| http://purl.uniprot.org/uniprot/#_Q99KY8-mappedCitation-22973541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22973541 |
| http://purl.uniprot.org/uniprot/#_Q07079-mappedCitation-22973541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22973541 |
| http://purl.uniprot.org/uniprot/#_P47877-mappedCitation-22973541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22973541 |
| http://purl.uniprot.org/uniprot/#_Q3TT49-mappedCitation-22973541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22973541 |