| http://purl.uniprot.org/citations/22980978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22980978 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription elongation is increasingly recognized as an important mechanism of gene regulation. Here, we show that microprocessor controls gene expression in an RNAi-independent manner. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR. Rrp6 further processes the cleavage product, which generates a small RNA that is required to mediate potent transcriptional repression and chromatin remodeling at the HIV-1 promoter. Using chromatin immunoprecipitation coupled to high-throughput sequencing (ChIP-seq), we identified cellular gene targets whose transcription is modulated by microprocessor. Our study reveals RNAPII pausing and premature termination mediated by the co-operative activity of ribonucleases, Drosha/Dgcr8, Xrn2, and Rrp6, as a regulatory mechanism of RNAPII-dependent transcription elongation."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.08.004"xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Berkhout B."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Benkirane M."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Rousset E."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Boyer F."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Parrinello H."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Wagschal A."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Contreras X."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Basavarajaiah P."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Kiernan R."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Harwig A."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Terzian C."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Laurent-Chabalier S."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/author | "Meziane O."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/pages | "1147-1157"xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/title | "Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII."xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/22980978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22980978 |