| http://purl.uniprot.org/citations/22982862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22982862 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of apoptosis involves a complicated cascade requiring numerous protein interactions including the pro-apoptotic executioner protein caspase-3 and the anti-apoptotic calcium-binding protein calbindin-D28K. Using isothermal titration calorimetry, we show that calbindin-D28K binds caspase-3 in a Ca(2+)-dependent fashion. Molecular docking and conformational sampling studies of the Ca(2+)-loaded capase-3/calbindin-D28K interaction were performed in order to isolate potentially crucial intermolecular contacts. Residues in the active site loops of caspase-3 and EF-hands 1 and 2 of calbindin-D28K were shown to be critical to the interaction. Based on these studies, a model is proposed to help understand how calbindin-D28K may deactivate caspase-3 upon binding."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.08.032"xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/author | "Thompson R.J."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/author | "Bobay B.G."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/author | "Cavanagh J."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/author | "Varney K.M."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/author | "Stewart A.L."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/author | "Tucker A.T."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/pages | "3582-3589"xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/title | "Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3."xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/22982862 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22982862 |
| http://purl.uniprot.org/citations/22982862 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22982862 |
| http://purl.uniprot.org/uniprot/#_P42574-mappedCitation-22982862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22982862 |
| http://purl.uniprot.org/uniprot/#_P05937-mappedCitation-22982862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22982862 |
| http://purl.uniprot.org/uniprot/P42574 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22982862 |
| http://purl.uniprot.org/uniprot/P05937 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22982862 |