| http://purl.uniprot.org/citations/22982990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22982990 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a mechanism is available to antibodies. Here we report the isolation and characterization of an antibody called C05, which neutralizes strains from multiple subtypes of influenza A virus, including H1, H2 and H3. X-ray and electron microscopy structures show that C05 recognizes conserved elements of the receptor-binding site on the haemagglutinin surface glycoprotein. Recognition of the haemagglutinin receptor-binding site is dominated by a single heavy-chain complementarity-determining region 3 loop, with minor contacts from heavy-chain complementarity-determining region 1, and is sufficient to achieve nanomolar binding with a minimal footprint. Thus, binding predominantly with a single loop can allow antibodies to target small, conserved functional sites on otherwise hypervariable antigens."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature11414"xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Khayat R."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Palese P."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Ward A.B."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Horowitz M."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Lerner R.A."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Ekiert D.C."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Bhabha G."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Steel J."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Kashyap A.K."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Bhatt R.R."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Webby R."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Rubrum A."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Dillon M.A."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Faynboym A.M."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "Horowitz L."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/author | "O'Neil R.E."xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/pages | "526-532"xsd:string |
| http://purl.uniprot.org/citations/22982990 | http://purl.uniprot.org/core/title | "Cross-neutralization of influenza A viruses mediated by a single antibody loop."xsd:string |