| http://purl.uniprot.org/citations/2298738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2298738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2298738 | http://www.w3.org/2000/01/rdf-schema#comment | "Three polypeptide neurotoxins (curtatoxins) were isolated from the venom of the spider Hololena curta by reverse-phase high performance liquid chromatography, gel permeation, and ion-exchange chromatography. The purified toxins induced an immediate paralysis in the cricket Acheta domestica that resulted in desiccation and death of the insect within 24-48 h (LD50 congruent to 4-20 micrograms/g); this toxic effect is consistent with irreversible presynaptic neuromuscular blockade. Curtatoxins are a class of sequence-related, cysteine-rich, carboxyl-terminal amidated polypeptides of 36 to 38 amino acid residues. The cysteine residues are conserved at identical sequence positions among these polypeptides and form 4 intramolecular disulfide bonds. Hydropathy calculations show that the toxins have an internal hydrophobic region flanked by hydrophilic and oppositely charged amino- and carboxyl-terminal ends. By analogy to other cysteine-rich arthropod venom proteins, the folded structure of the curtatoxins is likely important for their target specificity and mode of action at the neuromuscular junction."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)39939-9"xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)39939-9"xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Blankenship D.T."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Blankenship D.T."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Cardin A.D."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Cardin A.D."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Manley G.D."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Manley G.D."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Ackermann D.L."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Ackermann D.L."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Chen T.-M."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Chen T.-M."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Coutant J.E."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Coutant J.E."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Gorder G.W."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Gorder G.W."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Palfreyman M.G."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Palfreyman M.G."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Stapleton A."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/author | "Stapleton A."xsd:string |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2298738 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |